讲座一

题  目：Why They Cannot Stop? ----Neural Circuits Associated with Compulsive Behavior of Addiction

主讲人：胡玉正博士

时  间：11月22日（周三）下午15：00-16：00

地  点：心理学院301

讲座二

题  目：The neural bases for the development of episodic memory in early childhood

主讲人：耿凤基博士

时  间：11月22日（周三）下午16：00-17：00

地  点：心理学院301

胡玉正博士简介：

胡玉正，男，美国卫生研究院药物滥用研究所研究院(Research Fellow)。研究方向为使用多模态神经影像（功能磁共振成像[fMRI], 弥散张量成像[DTI], 波普成像[MRS]）和神经调节技术（经颅磁刺激[TMS]，光遗传学技术[Optogenetics]）等技术在系统水平和细胞水平从学习、奖赏、认知控制、情绪等方面研究成瘾行为的脑机制，以第一或共同第一作者在JAMA Psychiatry, Brain, Journal of Neuroscience, Human Brain Mapping等国际期刊发表论文。

内容简介：

Substance use disorder (SUD), also known as drug addiction, constitutes a major public health problem, and is associated with high rates of crime, recidivism, and mortality. Understanding the neural circuit plasticity that occurs during the transition from initial drug exposure and reinforced drug taking, to compulsive drug taking behaviors (often followed by repetitive withdrawals from and relapses to the drug) is critically important in the development of more efficacious treatments for SUDs. Using resting-state functional magnetic resonance imaging (fMRI), we first identified distinct “go” and “stop” brain circuits, the imbalance of which was associated with compulsive behaviors of addiction in human drug users. Based upon these findings, a longitudinal study was designed using animal model to examine the causal relationships between drug taking, neural circuitry changes, and behavior alterations in addiction. A neuromodulation-based strategy is proposed for the treatment of addiction and related mental disorders such as gambling and internet addiction.

耿凤基博士简介:

耿凤基，马里兰大学心理系博士后。2012年在浙江大学心理系获得博士学位，2013年加入美国密西根大学人类发育发展中心， 2014年加入马里兰大学心理系并工作至今。主要研究兴趣包括应用脑电、磁共振和认知行为实验来研究儿童记忆发展的神经机制以及儿童记忆发展的个体差异。

内容简介:

Episodic memory refers to the ability remembering individual items and contextual details that surround these items. This memory ability develops rapidly and significantly during early childhood. Animal and human studies have indicated that hippocampus is an important neural structure underlying episodic memory. However, it is still unclear regarding how the structural and functional development of hippocampus fosters the development of episodic memory in early childhood. I will address how we use neuroimaging methods to investigate the neural substrates underlying the development of episodic memory in early childhood, including (1) event-related potentials (ERP) is used to examine the developmental trajectories of episodic memory in early childhood, (2) ultra-high resolution structural MRI is used to test how hippocampal subregions and subfields underlie the development of episodic memory in early childhood; (3) task and resting-state fMRI are combined to test the relation between hippocampal memory network and episodic memory in early childhood. Then, I will discuss the implications of these findings in terms of designing research-based interventions for children with difficulty in memory.